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MALE INFERTILITY:
Etiology, Investigation, and Treatment
The testes, vulnerable to systemic and environmental insult, play a vital role in a
man's ability to
father a child. Understanding this role is an important part of the complex process of evaluating and
treating the growing numbers of men seeking treatment for male infertility. The number of couples
affected by infertility is currently estimated to be 15% of all couples attempting to have children.
The difficulties are attributable to a significant male factor alone in 30% of couples and to a
combination of male and female factors in an additional 20%. Therefore, in 50% of all infertile
couples, an abnormal male factor contributes to reproductive failure.
The primary care practitioner often is the first health care professional the patient seeks and,
consequently, is responsible for the absolutely critical initial evaluation of the subfertile male. This
evaluation involves a thorough history and physical examination and laboratory tests, including at
least a semen analysis and hormonal evaluation. Finally, it may be appropriate to refer the couple
to an infertility specialist.
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